Research

Our lab is interested in understanding the epigenomic and gene regulatory mechanisms that shape brain function, both during normal postnatal development and in response to environmental challenges, such as exposure to substances of abuse. We aim to uncover how molecular changes influence brain maturation, neural circuitry complexity, and maladaptive plasticity, with a focus on the dynamic regulation of gene expression at the cell-type level.

Neuroepigenetics of Brain Development

Our lab investigates the complex processes of postnatal brain development, focusing on the epigenomic and gene regulatory dynamics that shape brain maturation. We are particularly interested in how these molecular changes contribute to the increasing complexity of brain circuitry and function. By investigating how the epigenome is regulated during critical developmental stages and how it responds to environmental stimuli, we aim to gain insights into the mechanisms underlying the formation of functional neural networks. Our research utilizes a range of tools, including single-cell genomics, spatial genomics, circuitry analysis, animal behavior studies, and computational analysis.

Neuroepigenetics of Addiction

In addition to studying brain development, our lab investigates how repetitive exposure to substances of abuse affects the brain at the molecular level. We are particularly focused on the epigenetic and gene regulatory changes that occur in response to such exposures. Our goal is to understand the cell-type-specific gene regulatory mechanisms that contribute to addiction, identifying how these changes drive maladaptive neural plasticity and influence addictive behaviors.